<p class="board_subject1" style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; font-weight: bold; font-size: 28px; text-align: center; color: rgb(102, 102, 102); font-family: NotoSansRN; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; font-size: 24pt; color: rgb(0, 0, 0);">고품질 오가노이드의 대량 생산 기반 기술 확보</span></p> <p class="board_subject1" style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; font-weight: bold; font-size: 28px; text-align: center; color: rgb(102, 102, 102); font-family: NotoSansRN; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; font-size: 24pt; color: rgb(0, 0, 0);"><br></span></p> <p class="board_subject2" style="padding: 0px; margin-top: 5px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; text-align: center; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; font-size: 14pt; color: rgb(0, 0, 0);">3차원 나노섬유 멤브레인으로 구현한 유니맷 플랫폼 개발</span></p> <p class="board_subject2" style="padding: 0px; margin-top: 5px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; text-align: center; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; font-size: 14pt; color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">□</span><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">동물대체시험법 및</span></strong><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">재생</span></strong><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">치료제 개발에 청신호</span></strong><span style="color: rgb(0, 0, 0);">가 켜졌다.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"> </span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">□ 한국연구재단(이사장 이광복)은</span><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">김동성 교수</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">(</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">포스텍</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">,</span><span style="color: rgb(0, 0, 0);"> </span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">제</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">1</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">저자 김도희 연구원</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">)</span><span style="color: rgb(0, 0, 0);"> </span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">연구팀과</span></strong><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">박태은 교수</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">(UNIST,</span><span style="color: rgb(0, 0, 0);"> </span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">제</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">1</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">저자 임현지 연구원</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">)</span><span style="color: rgb(0, 0, 0);"> </span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">연구팀</span></strong><span style="color: rgb(0, 0, 0);">이 공동으로</span><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">생체 기능을 구현한 오가노이드</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">*</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">를 균일하게 대량 생산할 수 있는 플랫폼을 개발</span></strong><span style="color: rgb(0, 0, 0);">했다고 밝혔다.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">* 오가노이드 : 줄기세포를 3차원적으로 배양하거나 재조합해 만든 장기유사체로 미니 장기, 유사 장기로도 불린다.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"> </span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">□</span><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">오가노이드</span></strong><span style="color: rgb(0, 0, 0);">는</span><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">실제 장기와 유사한 기능을 수행하는</span><span style="color: rgb(0, 0, 0);"> </span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">3</span></strong><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">차원 세포 구조체</span></strong><span style="color: rgb(0, 0, 0);">로, 인간 장기 발달, 질병 모델링, 재생 치료제 연구에서 주목받아 왔다.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">○ 그러나</span><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">오가노이드의 비균질성과 낮은 재현성 문제</span></strong><span style="color: rgb(0, 0, 0);">는 오가노이드의</span><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">대량 생산에 걸림돌</span></strong><span style="color: rgb(0, 0, 0);">이 되고 있으며, 이러한 문제는 임상시험 검증과 신약 개발 과정에서 오가노이드의 실질적인 활용을 제한하고 있다.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">○ 또한, 기존 기술로는 오가노이드를 대량으로 생산하는 데 한계가 있어,</span><span style="color: rgb(0, 0, 0);"> </span><strong style="padding: 0px; margin: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility;"><span style="color: rgb(0, 0, 0);">산업적 요구를 충족시키기에도 부족한 상황</span></strong><span style="color: rgb(0, 0, 0);">이다.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">.</span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);"><br></span></p> <p style="padding: 0px; margin-right: 0px; margin-left: 0px; -webkit-font-smoothing: antialiased; text-rendering: optimizelegibility; color: rgb(102, 102, 102); font-family: NotoSansRN; font-size: 16px; letter-spacing: -0.3px; word-spacing: -0.5px;"><span style="color: rgb(0, 0, 0);">  * 자세한사항은 원문링크 및 첨부파일을 참조바랍니다.(출처: 한국연구재단)</span></p>
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