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글로벌 허가동향 보고서 2025-2호 바이오시밀러 발간

글로벌 허가동향 보고서 2025-2호 바이오시밀러 발간 : 작성자, 카테고리, 작성일, 조회수, 원문,출처, 첨부파일 정보 제공
작성자	관리자	카테고리	기타
작성일	2025-03-04	조회수	2,818
원문	한국바이오의약품협회
출처	https://www.kobia.kr/bbs/board.php?tbl=notice&mode=VIEW&num=1175&category=&findEx=&findType=&findWord=&sort1=&sort2=&it_id=&shop_flag=&mobile_flag=&page=1
첨부파일	[KoBIA_Global Approval Report] 2025(2ȣ)_Biosimilar 바이오시밀러.pdf(4.34MB)내려받기

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[주요 내용]

ㅇ Biosimilar란?

- 바이오시밀러 정의

- 국가별 바이오시밀러 시장 활성화를 위한 정책 시행
ㅇ Biosimilar의 발전 과정
ㅇ Biosimilar 시장 동향
ㅇ Biosimilar 개발 및 승인

- EU 및 미국의 바이오시밀러 승인 누적 제품수

- 바이오시밀러 제품의 주요 성분
ㅇ 주목할 만한 바이오시밀러

- 블록버스터 의약품 'Humira'(adalimumab)의 바이오시밀러

- 2024년 가장 승인이 많았던 'Stelara'(ustekinumab)의 바이오시밀러

- 2024년 두번째로 승인이 많았던 'Eylea'/'Zaltrap'(aflibercept)의 바이오시밀러

- 앞으로가 기대되는 바이오시밀러
ㅇ 주요국 바이오시밀러 허가현황(2025년 2월 기준 정상의약품)

* 자세한 사항은 원문링크와 첨부파일을 참고하시기 바랍니다.(출처: 한국바이오의약품협회)

이전글 2023년 기준 의약품 소비량 및 판매액 통계
다음글 [JPM2025] 제약바이오 트렌드

연관컨텐츠: 글로벌 바이오시밀러 한국보건산업진흥원 글로벌 허가동향 허가동향 허가 보고서 산업정보

<img src="https://www.khidi.or.kr/resources/component/crosseditor/binary/images/images/000250/aW1hZ2U=_46.png" title="external_image" alt="external_image" style="vertical-align: baseline; border: 0px solid rgb(0, 0, 0);">
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<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-size: 11pt;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 돋움체, dotumche; font-size: 10pt;"><span style="box-sizing: inherit; text-size-adjust: none; font-size: 11pt; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic;"><b style="box-sizing: inherit; text-size-adjust: none;">[주요 내용]</b></span></span></span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255);"><span style="box-sizing: inherit; text-size-adjust: none; font-size: 11pt;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 돋움체, dotumche; font-size: 10pt;"><span style="box-sizing: inherit; text-size-adjust: none; font-size: 10pt; color: rgb(60, 63, 69);"></span></span></span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ Biosimilar란? </span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;">   - 바이오시밀러 정의</span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;">   - 국가별 바이오시밀러 시장 활성화를 위한 정책 시행<br style="box-sizing: inherit; text-size-adjust: none;"></span><span style="box-sizing: inherit; text-size-adjust: none;"><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ Biosimilar의 발전 과정</span><br style="box-sizing: inherit; text-size-adjust: none;">
 <span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ Biosimilar 시장 동향</span><br style="box-sizing: inherit; text-size-adjust: none;">
 <span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ Biosimilar 개발 및 승인</span></span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;">   - EU 및 미국의 바이오시밀러 승인 누적 제품수</span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;">   - 바이오시밀러 제품의 주요 성분<br style="box-sizing: inherit; text-size-adjust: none;"></span><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ 주목할 만한 바이오시밀러</span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;">   - 블록버스터 의약품 'Humira'(adalimumab)의 바이오시밀러</span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;">   - 2024년 가장 승인이 많았던 'Stelara'(ustekinumab)의 바이오시밀러</span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;">   - 2024년 두번째로 승인이 많았던 'Eylea'/'Zaltrap'(aflibercept)의 바이오시밀러</span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;">   - 앞으로가 기대되는 바이오시밀러<br style="box-sizing: inherit; text-size-adjust: none;"></span><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ 주요국 바이오시밀러 허가현황(2025년 2월 기준 정상의약품)</span><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; font-size: 11pt;"> </span></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255);"><br style="box-sizing: inherit; text-size-adjust: none;"></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255);"><br style="box-sizing: inherit; text-size-adjust: none;"></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255);"><br style="box-sizing: inherit; text-size-adjust: none;"></p>
<p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="color: rgb(37, 37, 37); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">  * 자세한 사항은 원문링크와 첨부파일을 참고하시기 바랍니다.(출처: 한국바이오의약품협회)</span></p>
<div><span style="box-sizing: inherit; text-size-adjust: none; font-size: 11pt; color: rgb(0, 0, 0);"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 돋움체, dotumche; font-size: 10pt; color: rgb(37, 37, 37);"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; font-size: 11pt;"><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(0, 0, 0);"><br></span></span></span></span></div>

<img src="https://www.khidi.or.kr/resources/component/crosseditor/binary/images/images/000250/aW1hZ2U=_46.png" title="external_image" alt="external_image" style="vertical-align: baseline; border: 0px solid rgb(0, 0, 0);"> <p><br></p> <p><br></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-size: 11pt;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 돋움체, dotumche; font-size: 10pt;"><span style="box-sizing: inherit; text-size-adjust: none; font-size: 11pt; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic;"><b style="box-sizing: inherit; text-size-adjust: none;">[주요 내용]</b></span></span></span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255);"><span style="box-sizing: inherit; text-size-adjust: none; font-size: 11pt;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 돋움체, dotumche; font-size: 10pt;"><span style="box-sizing: inherit; text-size-adjust: none; font-size: 10pt; color: rgb(60, 63, 69);"></span></span></span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ Biosimilar란? </span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;"> - 바이오시밀러 정의</span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;"> - 국가별 바이오시밀러 시장 활성화를 위한 정책 시행<br style="box-sizing: inherit; text-size-adjust: none;"></span><span style="box-sizing: inherit; text-size-adjust: none;"><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ Biosimilar의 발전 과정</span><br style="box-sizing: inherit; text-size-adjust: none;"> <span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ Biosimilar 시장 동향</span><br style="box-sizing: inherit; text-size-adjust: none;"> <span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ Biosimilar 개발 및 승인</span></span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;"> - EU 및 미국의 바이오시밀러 승인 누적 제품수</span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;"> - 바이오시밀러 제품의 주요 성분<br style="box-sizing: inherit; text-size-adjust: none;"></span><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ 주목할 만한 바이오시밀러</span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;"> - 블록버스터 의약품 'Humira'(adalimumab)의 바이오시밀러</span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;"> - 2024년 가장 승인이 많았던 'Stelara'(ustekinumab)의 바이오시밀러</span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;"> - 2024년 두번째로 승인이 많았던 'Eylea'/'Zaltrap'(aflibercept)의 바이오시밀러</span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; color: rgb(60, 63, 69); font-size: 11pt;"> - 앞으로가 기대되는 바이오시밀러<br style="box-sizing: inherit; text-size-adjust: none;"></span><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(60, 63, 69); font-family: 나눔고딕, NanumGothic; font-size: 11pt;">ㅇ 주요국 바이오시밀러 허가현황(2025년 2월 기준 정상의약품)</span><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; font-size: 11pt;"> </span></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255);"><br style="box-sizing: inherit; text-size-adjust: none;"></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255);"><br style="box-sizing: inherit; text-size-adjust: none;"></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(125, 125, 125); font-family: 'Nanum Gothic'; font-size: 13px; background-color: rgb(255, 255, 255);"><br style="box-sizing: inherit; text-size-adjust: none;"></p> <p nanum="" font-size:="" 13px;="" background-color:="" rgb(255,="" 255,="" 255);="" line-height:="" style="box-sizing: inherit; text-size-adjust: none; margin-right: 0px; margin-left: 0px; padding: 0px; background-color: rgb(255, 255, 255); line-height: 1.8;"><span style="color: rgb(37, 37, 37); font-family: 나눔고딕, NanumGothic; font-size: 11pt;"> * 자세한 사항은 원문링크와 첨부파일을 참고하시기 바랍니다.(출처: 한국바이오의약품협회)</span></p> <div><span style="box-sizing: inherit; text-size-adjust: none; font-size: 11pt; color: rgb(0, 0, 0);"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 돋움체, dotumche; font-size: 10pt; color: rgb(37, 37, 37);"><span style="box-sizing: inherit; text-size-adjust: none; font-family: 나눔고딕, NanumGothic; font-size: 11pt;"><span style="box-sizing: inherit; text-size-adjust: none; color: rgb(0, 0, 0);"><br></span></span></span></span></div>
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