Development of novel broad spectrum of antiviral immunoglobulin, hzVSF SphereInfectious Diseases Summary - Virus Suppressing Factor (VSF) was isolated from virus-infected mouse. The ImmuneMed Inc., further developed to humanized immunoglobulin, hzVSF, and applies to anti-viral and anti-inflammatory treatment - VSF receptor (VR) against hzVSF expresses only in virus-infected cells, and hzVSF regulates the cell through the receptor. - Because hzVSF is targeting to virus-infected cells, hzVSF shows the therapeutic effect for a variety of viral infection including influenza virus, hepatitis B and C virus. Remarkable - Anti-viral substance which is secreted from encephalomyocarditis virus (EMCV) infected mouse was isolated. - The isolated substance was named Virus Suppressing Factor (VSF) and humanized to human immunoglobulin to further use. - VSF receptor (VR) against hzVSF was identified and elucidated the binding. VR does not express the healthy cell, but find only specific expression on the virus-infected cells. - hzVSF targets a common characterization of the host cell due to viral infection. - ImmuneMed discovers novel specific target protein that expresses only in the viral infected cells for the World`s first. ∙ It is possible to develop in multi-purpose anti-viral therapeutic agent for a varietyspectrum of virus. ∙ hzVSF will be solve the drug-resistant problem caused by frequent mutations of the virus. - Using in silico immunoprofiling sevice and in vitro cellular assay, the candidate substance which shows less immunogenic and enhanced anti-viral activity was deduced and determined. - Features of candidate hzVSF ∙ Features of Effect: offer inhibition of viral replication and suppression of inflammation ∙ hzVSF suppresses the damage of viral infected cells caused by the immunopathological phenomena ∙ hzVSF can be clinically treated with a small amount due to VR which is only expressed in viral infected cells and will be less to cause side effects. ∙ hzVSF is effective after showing clinical symptoms in patients with acute or chronic viral diseases. Contact Point Contact Point - Company, Name in Charge, Phone, Fax, Email Company HTTC Name in Charge Kim Dae Hyon Phone 82 +82-881-2842 Fax Email technomart@khidi.or.kr List